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CJC-1295 with DAC is a synthetic version of growth hormone-releasing hormone (GHRH), designed to stimulate the body to release more growth hormone and boost insulin-like growth factor 1 (IGF-1) levels. It also contains “DAC” as an addon.
What if it was possible to extend the natural GH rhythm for days — without flattening the pulse-like pattern that makes it tick? That’s exactly what CJC-1295 with DAC does. It pairs a proven Hormone-Releasing Hormone analogue with a DAC (that’s “Drug Affinity Complex” in case you were wondering) that takes its half life from mere minutes to more than a week.
The result isn’t a constant, artificial hormonal flood that overwhelms the system as synthetic GH does, but a natural, pulsatile release. Research already strongly shows that CJC-1295 with DAC has the potential to support lean mass gains. Because as research shows — it optimizes IGF-1 levels for six to eight days at a time, CJC-1295 with DAC also comes with a serious metabolic boost for better fat burning.
Metabolic optimization and muscle mass observed in research might be why CJC-1295 with DAC grabs headlines, but this peptide is also researched for its ability to speed up and improve cell repair, kick sleep quality up a few notches, and sharpen the brain.
Of interest to researchers who want to find out what a stable, rhythmic growth hormone boost can do — with the convenience of less frequent dosing.
Your work depends on consistency and precision, so you need a research peptide provider that’s equally steady. There’s nothing worse than having your research thrown off by unreliable peptide quality or shipping, after all.
CellPeptides gets it right on both counts. Our CJC-1295 with DAC:
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This GH and IGF-1 peptide is most famous for its extended-release action, and the science behind that definitely warrants a closer look — especially for researchers wondering whether “with DAC” or “without DAC” is the right choice.
CJC-1295 is the synthetic answer to Growth Hormone-Releasing Hormone — the natural hypothalamic peptide that binds the GHRH receptor to stimulate the growth hormone pulses that support metabolic processes, grow muscles, repair damage, and much more. It’s the first 29 amino acids of GHRH. The part that activates the receptor and makes the hormone work.
DAC — a small moiety hitching a ride on the peptide’s structure — is what really makes CJC-1295 with DAC unique. DAC makes it possible for CJC-1295 to bind to albumin reversibly. That stops the peptide from degrading for six to eight days and results in steady, natural GH pulses and the IGF-1 boost responsible for most of the peptide’s downstream effects.
Long story short? CJC-1295 with DAC has the benefits of growth hormone without reliance on synthetic hormones. That fact has led to interesting research applications. Bodybuilding and longevity are among them — but the scientific potential doesn’t end there.
Research into CJC-1295 with DAC started with one goal — to give patients with GH deficiency a much more convenient treatment option. One that didn’t depend on daily injections. It was successful in achieving that. Phase I and II clinical trials in healthy men demonstrated that CJC-1295 with DAC boosted growth hormone and IGF-1 levels, safely and effectively for a maximum of two weeks at a time. [1]
That’s what the compound does best, but research has taken some interesting directions. Curious? Read about them here.
Both animal studies and human trials have consistently shown that CJC-1295 with DAC successfully boosts growth hormone release — and that it preserves natural pulsatility as it does its work. [2] That makes it interesting for longer-term studies into muscle growth and the prevention of atrophy. Among the research applications? Sarcopenia caused by aging, athletic uses, and muscle loss caused by chronic illness or after surgery. As the whole body shifts toward protein synthesis, CJC-1295 has a strong anabolic effect. DAC keeps it working.
CJC-1295 with DAC might be best known for its effect on growth hormone pulses, but its impact on IGF-1 is just as interesting in research applications. IGF-1 is, of course, necessary for repair — of muscles, ligaments, and tendons, by way of stimulating fibroblast production. [3] Research looking at the potential for CJC-1295 to speed up healing has had promising results, and its anti-inflammatory action contributes to the process, too.
The fact that growth hormone can induce lipolysis — burn fat by encouraging the body to use it for energy — is already well established [4]. It’s no wonder that CJC-1295 with DAC is interesting to researchers investigating targeted fat loss that preserves muscle mass, too. Research into the fat burning potential of CJC-1295 with DAC is still in its early stages, so watch out for new studies. The most promising areas include sports medicine and fat burning in menopausal women struggling with sudden gains.
Anecdotal reports that CJC-1295 with DAC improves sleep quality have caught the attention of peptide researchers, too. It makes sense, because optimal growth hormone levels have been found to stabilize disrupted, disordered sleep patterns. [5] Deep, restorative sleep is linked to the most effective GH pulses.
Finally, and likely most interesting to many researchers, is its effect on age-related decline. Growth hormone steadily goes down — a fact that research clearly links to muscle loss, sagging skin, and even declining cognitive power. [6] What if stimulating GH pulses could “fix” some of those effects of aging? It’s a question begging for an answer, so it’s not surprising that CJC-1295 with DAC has created quite the buzz among biohackers chasing longevity.
The short answer? Any researcher whose study design calls for prolonged growth hormone and IGF-1 boosts. DAC eliminates the need for daily dosing by extending the half life of CJC-1295, so this compound is a good candidate for long-term experiments.
CJC-1295 with DAC might be of interest to you if your research focus is:
CJC-1295 without DAC is the better option for short-term studies that call for precision, but DAC adds a layer of convenience. Our pharmaceutical-grade CJC-1295 with DAC gives researchers a predictable GH and IGF-1 surge with weekly dosing.
CJC-1295 with DAC has one major advantage — with its long half life of six to eight days, the need for daily dosing goes out the window. Researchers who have worked with CJC-1295 without DAC already will be excited by the prospect of less frequent administration.
Dosing protocols should take this into account, although they of course depend on the study design and goals. Anti-aging and fat metabolism studies tend to rely on dosing between 1 and 2 mg. Muscle growth and tissue healing research calls for higher doses — usually 2 to 3 mg. In both cases, weekly administration is the default model. Review the literature to learn more about other dosing models.
Prepare dry CJC-1295 with DAC for multi-dose applications by reconstituting it with BAC water; 2 mL for a 5 mg vial. Swirling or rolling is the way to go, because shaking can compromise the peptide. After reconstitution, the compound can safely be stored between 2 and 8 °C to allow for multi-dose use.
Lab protocols apply when doing peptide research — wipe the stoppers with alcohol wipes, wear gloves, work with sterile syringes, and keep lab logs to document your research progress.
And in order to find out the exact dosages you might need for your research – feel free to use our comprehensive peptide dosage calculator here.
How do I know if CJC-1295 with or without DAC is the better choice?
DAC gives CJC-1295 a significantly longer half life — so that daily administration can become weekly dosing. That’s convenient. It makes CJC-1295 with DAC best for longer studies. Not all study designs benefit from this less frequent administration, though, and researchers choose CJC-1295 (without DAC) to observe acute effects.
Has CJC-1295 with DAC been shown to help with weight loss?
Studies have demonstrated that a GH boost can induce targeted fat loss. In CJC-1295 studies, the observed fat loss (without muscle loss!) is usually seen as a side benefit, as the research focus tends to be broader.
What are the advantages of stacking CJC-1295 with DAC and Ipamorelin?
These peptides belong to different classes — CJC-1295 is a GHRH analogue, and Ipamorelin a GHRP. Together, data suggests that they induce more balanced GH pulses. That’s why it’s a common combination.
| Amino Acid Sequence: | Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-NH₂ |
|---|---|
| Molecular Weight: | 3,369.1 g/mol |
| Molecular Formula: | C₁₅₂H₂₅₁N₄₃O₄₃ |
| CAS Number: | 863288-34-0 |